Phone around and see if you can get a pet sitter to come in and visit once or twice a day.
He probably would be okay but I could never leave my two for so long. I would spend the whole time worrying about them.
I left them overnight once and parts of the house were still untouched by bored claws - they were fine.
As Hopkirk says you might have inappropriate soiling in strange places -
http://www.icatcare.org/advice/problem-behaviour/soiling-indoors
Good luck to you and your boy