LuBlu, thank you for the kind word. However, I would encourage you to consider being slightly farther uptown. My thought is tri-fold: Noise, accessability, and safety. (yes, I know, there are police on every corner at Times Square)...that certainly doesn't make it 'safe.'
If you�re looking for some other options, in the mid-price range is the Buckingham at 57th and 6th
http://buckinghamhotel.com/hotel/hotel.cfm
Nearby would be the famous Carnegie Deli at 54th and 7th, which you may have seen in some of Woody Allen�s films (Manhattan, Broadway Danny Rose, etc.), a couple of blocks north is Central Park and a couple of blocks east is Fifth Avenue, where you can turn left and hit Bergdorf Goodman�s and Tiffany�s, or head south and cover Brooks Brothers, Cartier, Saks Fifth Avenue and everything in between.
In the same area as the other hotels you listed, you might wish to look at the QT. Again, not what I would typically use, but certainly different:
http://www.tablethotels.com/Hotel/en/6666/Revi ew/The-hotel-QT/New-York-New-York-USA?_SID_=20 071018175154-ab630594556e5280baafa53076844d54
Despite the Times Square being cleaned up quite a bit, it still remains a magnet for some interesting characters. I�d rather scoot over to Madison Avenue and stay at the old Roosevelt, which certainly may appeal to your in law�and you have all the benefits of Grand Central Station, the famous Oyster Bar, Brooks Brothers, etc. all at your fingertips.
I wish you well
Fr Bill